Exploring the correlation between serum creatinine and uric acid as predictors of kidney failure progression in hemodialysis patients: A study at the Multan institute of kidney diseases

Abstract

Background:
Kidney failure is a severe global health concern, emphasizing the need for reliable biomarkers to monitor disease progression. Serum creatinine and uric acid have been proposed as potential indicators of renal function decline. This study evaluates the correlation between serum creatinine and uric acid levels and their potential predictive value in assessing disease progression in patients undergoing hemodialysis.

Materials and Methods:
A descriptive observational study was carried out at the Multan Institute of Kidney Diseases, Multan, Pakistan, involving 100 patients receiving maintenance hemodialysis. Serum creatinine and uric acid levels were measured periodically. In addition, demographic data, clinical history, and laboratory findings were documented. Correlation analysis and multivariate regression were used to examine the association between these biomarkers and the progression of kidney failure.

Objectives:
To explore the relationship between serum creatinine and uric acid levels in patients with End-Stage Renal Disease (ESRD) undergoing hemodialysis. The study aims to enhance the understanding of these biomarkers' potential role in the progression and management of chronic kidney disease (CKD).

Results:
The analysis revealed a significant positive correlation between serum creatinine and uric acid levels. Patients with hyperuricemia were found to have a higher risk of CKD progression and reduced survival rates. Notably, those undergoing hemodialysis exhibited the highest serum creatinine levels. These findings indicate that elevated uric acid levels may be linked to more severe renal impairment and worse clinical outcomes.