Structural Prediction of Pathogenic Factors of Neisseria Meningitidis using Comparative Modeling

Authors

  • Rafia Safdar Department of Biochemistry, University of Karachi, Karachi-75270, Pakistan
  • Yasmeen Rashid Department of Biochemistry, University of Karachi, Karachi-75270, Pakistan

Abstract

Neisseria meningitidis, a gram-negative diplococcus and the causative agent of meningitis and severe sepsis, is known to occur in five different pathogenic strains including A, B, C, W-135, and Y. Vaccines against all strains are available except strain B due to its poor immunogenicity. Functional genomics studies of N. meningitidis serogroup-B revealed some of its proteins to be crucial for its pathogenesis. Here, we report 3D homolog models of NMB1728, NMB1527, and NMB1729 proteins. The homology models were constructed by the MODELLER program. Model structures were shown to have overall good stereochemistry as well as lower internal energy. The lower rmsd values for the models of these proteins showed overall structural resemblance including active site residues with their selected templates.

Pak. J. Biochem. Mol. Biol., 2018, 51 (1-2)

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Published

2018-06-30

How to Cite

Safdar, R., & Rashid, Y. (2018). Structural Prediction of Pathogenic Factors of Neisseria Meningitidis using Comparative Modeling. PAKISTAN JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 51(1-2), 15–30. Retrieved from http://pjbmb.com/index.php/pjbmb/article/view/27

Issue

Vol. 51 No. 1-2 (2018): PAKISTAN JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY

Section

Articles