Endogenous antimicrobial peptides as markers of immune status

Authors

  • Z.R. Hidayatova Biochemistry department, Azerbaijan Medical University, Baku, Azerbaijan
  • M.F. Amirova Biochemistry department, Azerbaijan Medical University, Baku, Azerbaijan
  • A.R. Dadasheva Biochemistry department, Azerbaijan Medical University, Baku, Azerbaijan
  • G.I. Azizova Biochemistry department, Azerbaijan Medical University, Baku, Azerbaijan
  • H.M. Osmanov Biochemistry department, Azerbaijan Medical University, Baku, Azerbaijan

Keywords:

defensins, endogenous antimicrobial peptides, circulating immune complexes

Abstract

The aim of this work was to study the role of endogenous peptides in toxification processes, as well as their relationship with the immune system indicators in the development of chronic viral hepatitis C. For this purpose, endotoxins and lipopolysaccharide-binding protein (LSP) were determined by enzyme-linked immunosorbent assay (ELISA). Moreover, lymphocyte subpopulation was estimated by an indirect immunofluorescent reaction (NIFR) and whereas the reaction of rat monoclonal antibodies to lymphocytic antigens was determined. In connection with the data obtained, we consider it expedient to use the endotoxin determination method as an additional marker of the severity of liver damage in patients with chronic viral hepatitis C. It seems also possible to identify endotoxins, defensin, and lipopolysaccharide-binding protein as markers of viral and bacterial infections.

Pak. J. Biochem. Mol. Biol., 2019, 52(3)

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Published

2021-10-29

How to Cite

Hidayatova, Z., Amirova, M., Dadasheva, A., Azizova, G., & Osmanov, H. (2021). Endogenous antimicrobial peptides as markers of immune status. PAKISTAN JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY, 52(3), 118–125. Retrieved from http://pjbmb.com/index.php/pjbmb/article/view/39

Issue

Vol. 52 No. 3 (2019): PAKISTAN JOURNAL OF BIOCHEMISTRY AND MOLECUALR BIOLOGY

Section

Articles